Honestly, yes. For the most part, yes.
Because generally speaking, unless you're coming from a culture where reading right to left is correct; it is sort of a needless addition. Which isn't to say I wouldn't read a scanlation in right to left form, or that I'd deny myself from looking at a really good comic that just so happens to function that way. But, if your native skill set happens to be left to right and you're going out of your way to make me read it backwards for the sake of emulating another style; I will consider it a deal breaker.
Because it breaks immersion. It breaks the buy-in. I can fully understand why when I'm reading a scanned translation that things are as they are; because it wasn't created for me as the target audience. It wasn't created for me Joe Schmo Americano to read outside its native language. So I will take that buy-in, that acceptance of it.
But if you're just some westerner who wants it to look more "genuine" or "true to style" or "manga" and I am your target audience by sake alone of being a westerner; then you have no excuse for the buy-in. You're creating an additional step that prevents me from wanting to dive into your work. You're actually going out of your way to make it harder for me to read something by making me rework my entire method that's been drilled into me ever since I picked up "See Spot Run" at the tender age of two years old.
The translation can get away with it; that's a step towards making it easier for me to read. Emulation however, is a step away.
That is just my taste though. Ultimately you can do whatever you want, but if you want to keep your barrier of entry and buy-in lower; just play to the skill-set everyone whose looking at your project already possesses. And obviously I'm coming at this from an "English is the language of the person reading it" point of view; but we do have to accept that is easily factored into the question at hand.
If it is an artistic choice and you've got the styles of Akira Kurosawa but in comic form; you do as you do. It'l be gold regardless. But if you're wanting to not plant any second thought in the barrier to entry, I'd vie against right to left unless that happens to be your native skill set.
I'm not going to say I don't read right to left comics, or that I'm above them; but unless I'm seeking them out because I happen to want to read something like that I will view it as a barrier of entry.