Quickly? Plagiarism! Contribute to anti-diversity funds! Offer adds to Big Tobacco! Endorse American political candidates!
It's interesting that sex is the hot topic here. Censorship runs rampant but there's been amazing strides made to avoid such, especially in art. Self-censorship is another topic entirely but it's influenced by societal views. I wonder if this is tied to the (ill-conceived by my standards) notion that comics are not art? And particularly webcomics? When sex/sexual situations are depicted, it's often lewd or low-brow thus lending to this idea that it's simply an empty-minded indulgence.
But again, I totally understand that we MUST take our audience into consideration. The very community that builds our perspective will also be the community that we use to build our worlds. Integrity in one hand, viewer acceptance in another (catering aside).
When all's said and done, the thing I wouldn't do in my comic is break a character for an arc or a quick plot fix. The characters are so bloody important and it would be a travesty to change them against the grain of themselves.