I use a Wacom Bamboo Capture, which is a tablet that I believe isn't even being made anymore :B (I believe they've been replaced by the complete Intuos line) So it's an old model, but I love it > w <
To draw, I use a mixture of Paint Tool SAI and Photoshop CS6. I pre-made my panels in Photoshop - so they're saved as they're own file so when I start a new comic I just need to open the panels file and save the final comic as a separate file, meaning I don't have to redraw the panels every gosh darn time lol - and then I do the sketch/linework/coloring in Paint Tool SAI. I add the text and speech bubbles in Photoshop, then switch back to SAI to add the balloon tails as well as the white background on the speech bubbles (so that they aren't transparent) and then I reformat the comics in SAI for vertical (as they're vertical on Tapastic, but traditionally horizontal on its own website) and then switch BACK to Photoshop and save the images as .JPG's.
Phew.